R-BC154 acetate is a selective fluorescent α₉β₁ integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity^[1].

R-BC154 acetate has 3 times greater affinities for α₉β₁ (K_i=12.7 nM) relative to α₄β₁ (K_i=38.0 nM) under Ca²⁺/Mg²⁺ conditions in human glioblastoma LN18 cell lines^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

R-BC154 acetate (10 mg/kg; i.v.) acts as an in vivo probe for bone marrow haemopoietic stem cells in mice^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

1184.36

C₅₆H₆₅N₉O₁₄S₃

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org Biomol Chem. 2014 Feb 14;12(6):965-78.