Super-TDU TFA | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Super-TDU TFA

Super-TDU TFA 是一种特异性的 YAP 拮抗剂，可以靶向 YAP-TEAD 相互作用。Super-TDU TFA 可以抑制胃癌小鼠模型的肿瘤生长。

Super-TDU TFA Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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Super-TDU TFA 的其他形式现货产品:

Super-TDU

生物活性

Super-TDU TFA is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU TFA suppresses tumor growth in gastric cancer mouse model^[1].

体外研究
(In Vitro)

Super-TDU TFA downregulates expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU TFA inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Super-TDU TFA (intravenous Injection; 50 μg/kg or 500 μg/kg; per day) markedly decreases the sizes, weights of tumors, and YAP target genes in a dose-dependent manner in mice^[1].
Super-TDU TFA (Intravenous Injection; 250 μg/kg 500 μg/kg) has the t_1/2α of 0.78 hours and 0.82 hours; the C_max of 6.12 ng/mL and 13.3 ng/mL; the CL of 7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/cA nu/nu mice^[1]
Dosage:	50 μg/kg or 500 μg/kg
Administration:	Intravenous Injection; per day
Result:	Decreased the sizes, weights of tumors, and YAP target genes in a dose-dependent manner.

Animal Model:	BALB/cA nu/nu mice^[1]
Dosage:	250 μg/kg or 500 μg/kg (Pharmacokinetic Study)
Administration:	Intravenous Injection
Result:	The t_1/2α is 0.78 hours and 0.82 hours; the C_max is 6.12 ng/mL and 13.3 ng/mL; the CL is7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively.

分子量

5393.96

Formula

C₂₃₉H₃₇₁N₆₆O₇₁S

Sequence Shortening

SVDDHFAKSLGDTWLQIGGSGNPKTANVPQTVPMRLRKLPDSFFKPPE

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Jiao S, et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell. 2014 Feb 10;25(2):166-80.

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