Kauran-16,17-diol(Synonyms: ent-Kauran-16β,17-diol)

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Kauran-16,17-diol (Synonyms: ent-Kauran-16β,17-diol)

Kauran-16,17-diol (ent-Kauran-16β,17-diol) 是一个天然的二萜化合物，具有抗肿瘤诱导凋亡的活性。其抑制 LPS 诱导的RAW 264.7 细胞产生 NO 的 IC50 值为17 μM。

Kauran-16,17-diol(Synonyms: ent-Kauran-16β,17-diol)

Kauran-16,17-diol Chemical Structure

CAS No. : 16836-31-0

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生物活性

Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages[1][2].

体外研究
(In Vitro)

Kauran-16,17-diol (ent-Kauran-16β,17-diol) down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

306.48

Formula

C20H34O2
CAS 号

16836-31-0
中文名称

对映-贝壳杉-16β,17-二醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Alvaro Morales, et al. The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells. Apoptosis. 2011 Dec;16(12):1245-52.

    [2]. Nguyen Xuan Nhiem, et al. New ent-kauranes from the fruits of Annona glabra and their inhibitory nitric oxide production in LPS-stimulated RAW264.7 macrophages. Bioorg Med Chem Lett. 2015 Jan 15;25(2):254-8.

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