Kauran-16,17-diol(Synonyms: ent-Kauran-16β,17-diol)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Kauran-16,17-diol (Synonyms: ent-Kauran-16β,17-diol)

Kauran-16,17-diol (ent-Kauran-16β,17-diol) 是一个天然的二萜化合物，具有抗肿瘤诱导凋亡的活性。其抑制 LPS 诱导的RAW 264.7 细胞产生 NO 的 IC50 值为17 μM。

Kauran-16,17-diol(Synonyms: ent-Kauran-16β,17-diol)

Kauran-16,17-diol Chemical Structure

CAS No. : 16836-31-0

规格 价格 是否有货
1 mg ￥2000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages[1][2].

体外研究
(In Vitro)

Kauran-16,17-diol (ent-Kauran-16β,17-diol) down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

306.48

Formula

C20H34O2
CAS 号

16836-31-0
中文名称

对映-贝壳杉-16β,17-二醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Alvaro Morales, et al. The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells. Apoptosis. 2011 Dec;16(12):1245-52.

    [2]. Nguyen Xuan Nhiem, et al. New ent-kauranes from the fruits of Annona glabra and their inhibitory nitric oxide production in LPS-stimulated RAW264.7 macrophages. Bioorg Med Chem Lett. 2015 Jan 15;25(2):254-8.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务