Khellin(Synonyms: 呋喃并色酮)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Khellin (Synonyms: 呋喃并色酮)

Khellin 是一种呋喃并色酮，能从 Ammi visnuga L. 中提取得到。Khellin 是一种 EGFR 抑制剂，其 IC50 为 0.15 µM。Khelline 在体外具有抗增殖活性。Khellin 具有抗痉挛和冠状动脉舒张作用。

Khellin(Synonyms: 呋喃并色酮)

Khellin Chemical Structure

CAS No. : 82-02-0

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生物活性

Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects[1][2].

IC50 & Target

IC50: 0.15 µM (EGFR)[1]
体外研究
(In Vitro)

Khelline exhibits anti-proliferative activity for MCF-7 cells and Hela cells[1].
Khellin inhibits the pathways of Ca2+ influx which are activated by both noradrenaline and high K+[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

260.24

Formula

C14H12O5
CAS 号

82-02-0
中文名称

呋喃并色酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Abdel-Sattar S Hamad Elgazwy, et al. Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors. J Enzyme Inhib Med Chem. 2013 Dec;28(6):1171-81.

    [2]. A Ubeda, et al. Relaxant actions of khellin on vascular smooth muscle. J Pharm Pharmacol . 1989 Apr;41(4):236-41.

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