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Naftopidil hydrochloride (Synonyms: KT-611 hydrochloride; BM-15275 hydrochloride)
Naftopidil hydrochloride (KT-611 hydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂,对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力 Ki 值分别为 3.7 nM、20 nM、1.2 nM,具有抗增殖作用。Naftopidil hydrochloride 可用于前列腺增生的研究。
Naftopidil hydrochloride Chemical Structure
CAS No. : 1164469-60-6
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Naftopidil hydrochloride 的其他形式现货产品:
生物活性 |
Naftopidil hydrochloride (KT-611 hydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b– and α1d-adrenoceptor subtypes, respectively. Naftopidil hydrochloride has antiproliferative effects. Naftopidil hydrochloride can be used for the research of prostate hyperplasia[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
Naftopidil hydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[2]
Western Blot Analysis[2]
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体内研究 (In Vivo) |
Naftopidil hydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
428.95 |
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Formula |
C24H29ClN2O3 |
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CAS 号 |
1164469-60-6 |
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中文名称 |
萘哌地尔盐酸盐 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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