CID 5951923

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CID 5951923 

CID 5951923是一种有效的 Krüppel-like factor 5 (KLF5) 抑制剂,IC50 值为 603 nM,CID 5951923 可在体外抑制癌细胞的增殖。

CID 5951923

CID 5951923 Chemical Structure

CAS No. : 749872-43-3

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生物活性

CID 5951923 is a potent inhibitor of Krüppel-like factor 5 (KLF5), with an IC50 of 603 nM. CID 5951923 can inhibit proliferation of cancer cells in vitro[1].

IC50 & Target

IC50: 603 nM (KLF5)[1]

体外研究
(In Vitro)

CID 5951923 (1 nM-100 μM; 48 h) inhibits proliferation of DLD-1 cells in a dose-dependent manner[1].
CID 5951923 (10 μM; 24 h) significantly decreases endogenous KLF5 levels in the DLD-1 cells, increases phosphorylation levels of pEGFFpY1068, and downregulated EGR1[1].
CID 5951923 (10 μM) inhibits proliferation of cancer cell lines mainly in highly express KLF5 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: DLD-1 and IEC-6 cells
Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 48 h
Result: Inhibited proliferation of DLD-1 cells with an IC50 of 1.6 μM.

分子量

382.39

Formula

C16H18N2O7S

CAS 号

749872-43-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Bialkowska AB, et, al. Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening. Mol Cancer Ther. 2011 Nov; 10(11): 2043-51.

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