NSC 33994

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NSC 33994 

NSC 33994 (G6) 是选择性的 JAK2 抑制剂，其 IC50 值为 60 nM。

NSC 33994

NSC 33994 Chemical Structure

CAS No. : 82058-16-0

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生物活性

NSC 33994 (G6) is a selective JAK2 inhibitor, with an IC50 of 60 nM[1].

IC50 & Target[1]

JAK2

60 nM (IC50, JAK2 Val617Phe kinase activity )

体外研究
(In Vitro)

NSC 33994 (G6) reduces the levels of phospho-JAK2 in both a dose- and time-dependent manner[1].
NSC 33994 (G6, 0-25 μM, 0-48 h) inhibits phospho-JAK2 (pY1007/pY1008) in a dose-dependent and time-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

438.65

Formula

C28H42N2O2
CAS 号

82058-16-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Róbert Kiss, et al. Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3598-601.

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