上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
PD0166285 dihydrochloride
PD0166285 dihydrochloride是 P-gp 的一个底物,是 WEE1 抑制剂,也可微弱抑制 Myt1,IC50 值分别为 24 和 72 nM。PD0166285 dihydrochloride 对 Chk1 的 IC50 值为3.433 μM。
PD0166285 dihydrochloride Chemical Structure
CAS No. : 212391-63-4
规格 | 是否有货 | ||
---|---|---|---|
100 mg | 询价 | ||
250 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
PD0166285 dihydrochloride 的其他形式现货产品:
生物活性 |
PD0166285 dihydrochloride, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 dihydrochloride exhibits an IC50 of 3.433 μM for Chk1[1]. |
IC50 & Target |
IC50: 24 nM (WEE1), 72 nM (Myt1), 3.433 μM (Chk1)[1]. |
||||||
---|---|---|---|---|---|---|---|---|---|
体外研究 (In Vitro) |
PD0166285 (0.5 μM) dramatically inhibits irradiation-induced Cdc2 phosphorylation at the Tyr-15 and Thr-14 in seven of seven cancer cell lines[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[1]
|
||||||||
体内研究 (In Vivo) |
|
||||||||
分子量 |
585.35 |
||||||||
Formula |
C26H29Cl4N5O2 |
||||||||
CAS 号 |
212391-63-4 |
||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
||||||||
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务