Raloxifene(Synonyms: Keoxifene; LY156758 free base; LY139481)

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Raloxifene (Synonyms: Keoxifene; LY156758 free base; LY139481)

Raloxifene (Keoxifene) 是一种苯并噻吩类选择性雌激素受体 (estrogen receptor) 调节剂 (SERM),对骨、血脂有雌激素激动作用,对乳腺和子宫有雌激素拮抗作用。Raloxifene 用于乳腺癌和骨质疏松症研究。

Raloxifene(Synonyms: Keoxifene; LY156758 free base;  LY139481)

Raloxifene Chemical Structure

CAS No. : 84449-90-1

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Raloxifene 的其他形式现货产品:

Raloxifene hydrochloride

生物活性

Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research[1].

IC50 & Target

Estrogen receptor

 

体内研究
(In Vivo)

Raloxifene (4 mg/kg; intragastrically; daily for 13 weeks) significantly prevents bone loss in ovariectomized (OVX) rats[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female, 12-week-old, Wistar rats (OVX rats)[1]
Dosage: 4 mg/kg
Administration: Intragastrically; daily for 13 weeks
Result: Significantly increased the levels of E2 in OVX rats and significantly decreased the levels of BGP.

Clinical Trial

分子量

473.58

Formula

C28H27NO4S

CAS 号

84449-90-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Khovidhunkit W, et al. Clinical effects of raloxifene hydrochloride in women. Ann Intern Med. 1999;130(5):431-439.

    [2]. Xu H, et al. Effect of caffeine on ovariectomy-induced osteoporosis in rats. Biomed Pharmacother. 2019;112:108650.

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