PD0325901-O-C2-dioxolane

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PD0325901-O-C2-dioxolane 

PD0325901-O-C2-dioxolane 含有 MEK 抑制剂 PD0325901 主要部分。PD0325901-O-C2-dioxolane 和 VHL 或 CRBN E3 连接酶的配体可用于 MEK1/2 降解剂的合成。

PD0325901-O-C2-dioxolane

PD0325901-O-C2-dioxolane Chemical Structure

CAS No. : 2581116-22-3

规格 价格 是否有货
5 mg ￥2200 询问价格 & 货期
10 mg ￥3500 询问价格 & 货期
25 mg ￥7000 询问价格 & 货期
50 mg ￥11500 询问价格 & 货期

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生物活性

PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degrader[1].

IC50 & Target[1]

MEK1

 

MEK2

 

体外研究
(In Vitro)

PD0325901 is a non-ATP competitive MEK inhibitor, potently inhibits ERK signaling and proliferation of tumor cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

508.23

Formula

C18H16F3IN2O4
CAS 号

2581116-22-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader. J Med Chem. 2019;62(23):10897-10911.

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