O-Desmethyl Midostaurin-d5(Synonyms: CGP62221-d5; O-Desmethyl PKC412-d5)

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O-Desmethyl Midostaurin-d5 (Synonyms: CGP62221-d5; O-Desmethyl PKC412-d5)

O-Desmethyl PKC412-d5 (CGP62221-d5) 是 O-Desmethyl PKC412 的氘代物。O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) 是 Midostaurin (HY-10230) 的活性代谢物，通过细胞色素 P450 肝酶代谢产生，可以作为 Midostaurin 在体内代谢的指标之一。

O-Desmethyl Midostaurin-d5(Synonyms: CGP62221-d5; O-Desmethyl PKC412-d5)

O-Desmethyl Midostaurin-d5 Chemical Structure

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生物活性

O-Desmethyl PKC412-d5 (CGP62221-d5) is a deuterium labeled O-Desmethyl PKC412. O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism[1].

IC50 & Target

IC50: active metabolite of Midostaurin[1]
分子量

561.64

Formula

C34H23D5N4O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006 Nov 15;108(10):3477-83.

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