(3R,5S)-Fluvastatin(Synonyms: (3R,5S)-XU 62-320 free acid)

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(3R,5S)-Fluvastatin (Synonyms: (3R,5S)-XU 62-320 free acid)

(3R,5S)-Fluvastatin 是 Fluvastatin 的 3R,5S-异构体。Fluvastatin (XU 62-320 free acid) 是第一个完全合成的，竞争性的 HMG-CoA 还原酶 抑制剂，IC50 为 8 nM。Fluvastatin 通过依赖 Nrf2 的抗氧化通路保护血管平滑肌细胞免受氧化应激。

(3R,5S)-Fluvastatin(Synonyms: (3R,5S)-XU 62-320 free acid)

(3R,5S)-Fluvastatin Chemical Structure

CAS No. : 155229-75-7

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生物活性

(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2][3].

分子量

411.47

Formula

C24H26FNO4
CAS 号

155229-75-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Araújo FA, Rocha MA, Capettini LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24.

    [2]. Makabe S, Takahashi Y, Watanabe H, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84.

    [3]. Scripture CD, Pieper JA. Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81.

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