(3S,5R)-Fluvastatin D6(Synonyms: (3S,5R)-XU 62-320 free acid D6)

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(3S,5R)-Fluvastatin D6 (Synonyms: (3S,5R)-XU 62-320 free acid D6)

(3S,5R)-Fluvastatin D6 是 (3S,5R)-Fluvastatin sodium 的氘代物。Fluvastatin 是第一个完全合成的,竞争性的 HMG-CoA reductase 还原酶抑制剂,IC50 为 8 nM。Fluvastatin 通过依赖 Nrf2 的抗氧化通路保护血管平滑肌细胞免受氧化应激。

(3S,5R)-Fluvastatin D6(Synonyms: (3S,5R)-XU 62-320 free acid D6)

(3S,5R)-Fluvastatin D6 Chemical Structure

CAS No. : 2249799-34-4

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生物活性

(3S,5R)-Fluvastatin D6 is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].

分子量

417.50

Formula

C24H20D6FNO4

CAS 号

2249799-34-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Araújo FA, Rocha MA, Capettini LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24.

    [2]. Makabe S, Takahashi Y, Watanabe H, et al. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway. Atherosclerosis. 2010 Dec;213(2):377-84.

    [3]. Scripture CD, Pieper JA. Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81.

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