Cadein1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cadein1 

Cadein1 是一种异喹啉衍生物，在p53功能缺失的癌细胞中，可导致 G2/M 延迟和 caspase 依赖的凋亡。

Cadein1

Cadein1 Chemical Structure

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生物活性

Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53[1].

体外研究
(In Vitro)

Cadein1 may be a potent anti-cancer agent against human cancers, specifically p53-deficient cancers with functional MMR[1].
Cadein1 activates p38 in p53-defective cancer cells with functional MMR to induce cell death. Cadein1 (4 μM) induces p38 phosphorylation in a time-dependent manner in HeLa and HCT116-Ch3/E6 cells [1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

655.64

Formula

C33H48F2INO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Eun Ryoung Jang, et al. A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway. J Biol Chem. 2010 Jan 29;285(5):2986-95.

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