Asimilobine(Synonyms: 巴婆碱)

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Asimilobine (Synonyms: 巴婆碱)

Asimilobine 是从木兰的植物中分离出的一种阿朴啡型异喹啉生物碱。Asimilobine 是多巴胺 (dopamine) 生物合成的抑制剂，也是血清素能受体 (serotonergic receptor) 拮抗剂。Asimilobine 具有抗疟 (antimalarial) 和抗癌活性。

Asimilobine(Synonyms: 巴婆碱)

Asimilobine Chemical Structure

CAS No. : 6871-21-2

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生物活性

Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity[1][2].

IC50 & Target[1][2]

Dopamine Receptor

 

serotonergic receptor

 

体外研究
(In Vitro)

Asimilobine (0.05-0.2 μM; for 24 h) shows a significant inhibition of intracellular dopamine levels in a concentration-dependent manner with an IC50 value of 0.13 μM[2].
Asimilobine (0.15 μM) inhibits tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities at 24 h[2].
Asimilobine also decreases TH mRNA levels and intracellular cyclic AMP levels[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

267.32

Formula

C17H17NO2
CAS 号

6871-21-2
中文名称

巴婆碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. N Shoji, et al. Asimilobine and Lirinidine, Serotonergic Receptor Antagonists, From Nelumbo Nucifera. J Nat Prod. Jul-Aug 1987;50(4):773-4.

    [2]. Chun-Mei Jin, et al. Effects of Asimilobine on Dopamine Biosynthesis and l-DOPA-induced Cytotoxicity in PC12 Cells. J Asian Nat Prod Res. Jul-Aug 2008;10(7-8):747-55.

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