Safracin B

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Safracin B 

Safracin B 是一种四氢异喹啉 (THIQ) 生物碱，是来自荧光假单胞菌的天然抗生素 (antibiotic)。Safracin B 具有广谱抗微生物和强大的抗肿瘤活性。

Safracin B

Safracin B Chemical Structure

CAS No. : 87578-99-2

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生物活性

Safracin B, a tetrahydroisoquinoline (THIQ) alkaloid, is a naturally occurring antibiotic from Pseudomonas fluorescens. Safracin B exhibits broad spectrum antimicrobial and strong antitumor activities[1].

体内研究
(In Vivo)

Safracin B (0.005-5 mg/kg/day; for 9 days) prolongs the life span of tumor-bearing mice and shows antitumor activity against L1210 and P388 leukemias and B16 melanoma in Female BALB/c x DBA/2 F1 (CD2F1) mice weighing 19-24 g[2].
The LD50 is 7.3 mg/kg with safracin B in normal CD2F1 mice by ip administration[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

540.61

Formula

C28H36N4O7
CAS 号

87578-99-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gong-Li Tang, et al.Biosynthesis of Tetrahydroisoquinoline Antibiotics. Curr Top Med Chem. 2016;16(15):1717-26.

    [2]. T Okumoto, et al. Activity of Safracins A and B, Heterocyclic Quinone Antibiotics, on Experimental Tumors in Mice. J Antibiot (Tokyo). 1985 Jun;38(6):767-71.

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