EAD1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

EAD1 

EAD1 是一种有效的自噬 (autophagy) 抑制剂，在肺癌和胰腺癌细胞中具有抗增殖活性。EAD1 还诱导凋亡 (apoptosis)。

EAD1

EAD1 Chemical Structure

CAS No. : 1644388-26-0

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生物活性

EAD1 is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 also induces apoptosis[1].

体外研究
(In Vitro)

EAD1 (0-200 μM; 72 hours) has antiproliferative activity against human cancer cell lines[1].
EAD1 (5-75 μM; 24 hours) induces apoptosis in the H460 cells in a concentration-dependent manner[1].
EAD1 (1-25 μM; 24 hour) increases the punctate LC3 signal in H460 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: H460 and HCC827 nonsmall cell lung cancer (NSCLC) and BxPC3 pancreatic cancer cells
Concentration: 0, 50, 100, 150, 200 μM
Incubation Time: 72 hours
Result: IC50s of 11, 7.6, and 5.8 μM for H460, HCC827, and BxPC3 cells, respectively.

Apoptosis Analysis[1]

Cell Line: H460 cells
Concentration: 5, 25, 50, and 75 μM
Incubation Time: 24 hours
Result: Induction of apoptosis.

Western Blot Analysis[1]

Cell Line: H460 cells
Concentration: 1, 2.5, 5, 10, 25 μM
Incubation Time: 24 hours
Result: Caused concentration and time-dependent increases in LC3-II levels.

分子量

484.42

Formula

C24H27Cl2N7
CAS 号

1644388-26-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lars Ulrik Nordstrøm, et al. Discovery of Autophagy Inhibitors With Antiproliferative Activity in Lung and Pancreatic Cancer Cells. ACS Med Chem Lett. 2015 Jan 8;6(2):134-9.

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