BH3 hydrochloride

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BH3 hydrochloride 

BH3 hydrochloride 是能透过血脑屏障的多肽，通过直接激活促凋亡 Bax/Bak 或通过中和抗凋亡 Bcl-2 蛋白 (Bcl-2、Bcl-XL、Bcl-w、mcl1和A-1)来诱导细胞凋亡，通过与BH3 结构域结合。

BH3 hydrochloride

BH3 hydrochloride Chemical Structure

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生物活性

BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian[1][2].

分子量

2677.45

Formula

C120H183ClN36O32
Sequence

Ile-Trp-Ile-Ala-Gln-Glu-Leu-Arg-Arg-Ile-Gly-Asp-Glu-Phe-Asn-Ala-Tyr-Tyr-Ala-Arg-Arg
Sequence Shortening

IWIAQELRRIGDEFNAYYARR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Guang Yang, et al. Modulating Protein-Protein Interactions In Vivo via Peptide-Lanthanide-Derived Nanoparticles for Hazard-Free Cancer Therapy. J Biomed Nanotechnol. 2019 Sep 1;15(9):1937-1947.

    [2]. Shatrunajay Shukla, et al. BH3-only Protein BIM: An Emerging Target in Chemotherapy. Eur J Cell Biol. 2017 Dec;96(8):728-738.

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