Lavendustin C(Synonyms: N-(2,5-二羟基苄基)-5-氨基水杨酸)

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Lavendustin C (Synonyms: N-(2,5-二羟基苄基)-5-氨基水杨酸)

Lavendustin C 是一种有效的 Ca2+ 钙调蛋白依赖性激酶 II (CaMK II) 抑制剂，IC50 为 0.2 µM。Lavendustin C 抑制 EGFR 相关酪氨酸激酶 (IC50=0.012 µM) 和pp60c-src(+) 激酶 (IC50=0.5 µM)。

Lavendustin C(Synonyms: N-(2,5-二羟基苄基)-5-氨基水杨酸)

Lavendustin C Chemical Structure

CAS No. : 125697-93-0

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生物活性

Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 µM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 µM) and pp60c-src(+) kinase (IC50=0.5 µM) [1][2].

IC50 & Target[1][2]

CaMK II

0.2 μM (IC50)

EGFR

0.012 μM (IC50)

体外研究
(In Vitro)

Lavendustin C (Compound 5) shows potent inhibitory activity, and it may be the core structure responsible for inhibition of tyrosine kinase[1].
Lavendustin C (10-150 µM) inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

275.26

Formula

C14H13NO5
CAS 号

125697-93-0
中文名称

N-(2,5-二羟基苄基)-5-氨基水杨酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. T Onoda, et al.Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, From Streptomyces Griseolavendus. J Nat Prod. Nov-Dec 1989;52(6):1252-7.

    [2]. T J O’Dell, et al.Long-term Potentiation in the Hippocampus Is Blocked by Tyrosine Kinase Inhibitors. Nature. 1991 Oct 10;353(6344):558-60.

    [3]. H M Burt, et al. Inhibition of Crystal-Induced Neutrophil Activation by a Protein Tyrosine Kinase Inhibitor. J Leukoc Biol. 1994 Jan;55(1):112-9.

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