Aeroplysinin 1(Synonyms: (+)-Aeroplysinin-1)

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Aeroplysinin 1 (Synonyms: (+)-Aeroplysinin-1)

Aeroplysinin 1 ((+)-Aeroplysinin-1)，从海洋海绵中分离出的次生代谢产物，对革兰氏阳性细菌 (bacteria) 显示出有效的抗生素作用，并具有针对 HIV-1 的抗病毒活性 (IC50=14.6 μM)。Aeroplysinin 1 具有抗炎，抗血管生成和抗肿瘤活性。Aeroplysinin 1诱导内皮细胞凋亡 (apoptosis)。

Aeroplysinin 1(Synonyms: (+)-Aeroplysinin-1)

Aeroplysinin 1 Chemical Structure

CAS No. : 28656-91-9

规格 价格 是否有货 数量
100 μg ￥5800 In-stock

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生物活性

Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells[1][2].

IC50 & Target[1]

Bacterial

 

HIV-1

14.6 μM (IC50)

Apoptosis

 

体外研究
(In Vitro)

Aeroplysinin 1 shows anti-proliferative effect against tumor cells (HT-1080, HTC-116, HeLa, THP-1, NOMO-1 and HL-60 cells), with IC50s ranging from 2.3 to 17 μM[1].
Aeroplysinin-1 also exhibits an antiviral activity toward HIV-1 caused by inhibition of its reverse transcriptase activity[1].
Aeroplysinin 1 inhibits P. phosphoreum, C. wailesii, P. minimum and HIV with IC50s of 3.5, 5.6, 7.0 and 14.6 μM[1].
Aeroplysinin 1 inhibits human endothelial cells (EVLC-2, HMEC, RF-24, and HUVEC cells), with IC50s ranging from 2.6 to 4.7 μM[2].
(+)-Aeroplysinin-1 (0.25-0.5 μM) blocks the EGF-dependent proliferation of both MCF-7 and ZR-75-1 human breast cancer cells and inhibits the ligand-induced endocytosis of the EGF receptor in vitro[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

338.98

Formula

C9H9Br2NO3
CAS 号

28656-91-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. García-Vilas JA, et al. Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug. Mar Drugs. 2015;14(1):1. Published 2015 Dec 22.

    [2]. Martínez-Poveda B, et al. The brominated compound aeroplysinin-1 inhibits proliferation and the expression of key pro- inflammatory molecules in human endothelial and monocyte cells. PLoS One. 2013;8(1):e55203.

    [3]. Kreuter MH, et al. Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1. Comp Biochem Physiol B. 1990;97(1):151‐158.

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