Aeroplysinin 1(Synonyms: (+)-Aeroplysinin-1)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Aeroplysinin 1 (Synonyms: (+)-Aeroplysinin-1)

Aeroplysinin 1 ((+)-Aeroplysinin-1)，从海洋海绵中分离出的次生代谢产物，对革兰氏阳性细菌 (bacteria) 显示出有效的抗生素作用，并具有针对 HIV-1 的抗病毒活性 (IC50=14.6 μM)。Aeroplysinin 1 具有抗炎，抗血管生成和抗肿瘤活性。Aeroplysinin 1诱导内皮细胞凋亡 (apoptosis)。

Aeroplysinin 1(Synonyms: (+)-Aeroplysinin-1)

Aeroplysinin 1 Chemical Structure

CAS No. : 28656-91-9

规格 价格 是否有货 数量
100 μg ￥5800 In-stock

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生物活性

Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells[1][2].

IC50 & Target[1]

Bacterial

 

HIV-1

14.6 μM (IC50)

Apoptosis

 

体外研究
(In Vitro)

Aeroplysinin 1 shows anti-proliferative effect against tumor cells (HT-1080, HTC-116, HeLa, THP-1, NOMO-1 and HL-60 cells), with IC50s ranging from 2.3 to 17 μM[1].
Aeroplysinin-1 also exhibits an antiviral activity toward HIV-1 caused by inhibition of its reverse transcriptase activity[1].
Aeroplysinin 1 inhibits P. phosphoreum, C. wailesii, P. minimum and HIV with IC50s of 3.5, 5.6, 7.0 and 14.6 μM[1].
Aeroplysinin 1 inhibits human endothelial cells (EVLC-2, HMEC, RF-24, and HUVEC cells), with IC50s ranging from 2.6 to 4.7 μM[2].
(+)-Aeroplysinin-1 (0.25-0.5 μM) blocks the EGF-dependent proliferation of both MCF-7 and ZR-75-1 human breast cancer cells and inhibits the ligand-induced endocytosis of the EGF receptor in vitro[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

338.98

Formula

C9H9Br2NO3
CAS 号

28656-91-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. García-Vilas JA, et al. Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug. Mar Drugs. 2015;14(1):1. Published 2015 Dec 22.

    [2]. Martínez-Poveda B, et al. The brominated compound aeroplysinin-1 inhibits proliferation and the expression of key pro- inflammatory molecules in human endothelial and monocyte cells. PLoS One. 2013;8(1):e55203.

    [3]. Kreuter MH, et al. Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1. Comp Biochem Physiol B. 1990;97(1):151‐158.

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