Neamine(Synonyms: 新霉胺) | whatman (沃特曼)

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Neamine (Synonyms: 新霉胺)

Neamine ，一种新霉素的降解产物，是一种广谱氨基糖苷类抗生素。Neamine 是靶向血管生成素 (angiogenin) 的抗血管生成剂。Neamine 具有有效的抗菌，抗肿瘤和神经保护活性。

Neamine Chemical Structure

CAS No. : 3947-65-7

规格		是否有货
5 mg		询价
10 mg		询价
25 mg		询价

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生物活性

Neamine, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting angiogenin. Neamine has potent antibacterial, antitumor and neuroprotective activities^[1]^[2].

体外研究
(In Vitro)

Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM^[1].
Neamine (100 μM) also blocks the nuclear translocation of ANG effectively^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	AsPC-1 cells
Concentration:	0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 25 µM
Incubation Time:	48 hours
Result:	Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation.

体内研究
(In Vivo)

Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells^[1]
Dosage:	30 mg/kg, 60 mg/kg
Administration:	Subcutaneous injection; daily; for 14 days
Result:	Had anti-tumor effects on AsPC-1 xenograft models.

分子量

322.36

Formula

C₁₂H₂₆N₄O₆

CAS 号

3947-65-7

中文名称

新霉胺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Ya-Ping Liu, et al. Neamine Inhibits Growth of Pancreatic Cancer Cells in Vitro and in Vivo. J Huazhong Univ Sci Technolog Med Sci. 2016 Feb;36(1):82-87.

[2]. R Ning, et al. Neamine Induces Neuroprotection After Acute Ischemic Stroke in Type One Diabetic Rats. Neuroscience. 2014 Jan 17;257:76-85.

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