Polyketomycin

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Polyketomycin 

Polyketomycin 是一种从链霉菌属中分离的四环醌糖苷抗生素。Polyketomycin 抑制革兰氏阳性细菌 (Gram-positive bacteria) 的生长，其 MIC 值小于 0.2 µg/mL。Polyketomycin 具有抗菌，抗癌，抗疟疾的作用。

Polyketomycin

Polyketomycin Chemical Structure

CAS No. : 200625-47-4

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生物活性

Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3].

IC50 & Target[1][2]

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC50 values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

The acute toxicity (LD50, ip) of Polyketomycin in mice is estimated to be 6.25-12.5mg/kg[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

864.84

Formula

C44H48O18
CAS 号

200625-47-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Momose I, et al. Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1998 Jan;51(1):21-5.

    [2]. Daum M, et al. Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem. 2009 Apr 17;10(6):1073-83.

    [3]. Otoguro K, In vitro antimalarial activities of the microbial metabolites. J Antibiot (Tokyo). 2003 Mar;56(3):322-4.

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