Azido-PEG1-CH2COO-Cl

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Azido-PEG1-CH2COO-Cl 

Azido-PEG1-CH2COO-Cl (compound 43a) 是一种 PROTAC linker，属于 alkyl/ether 类。可用于合成 PROTAC BRD4 Degrader-1 (HY-133131)。

Azido-PEG1-CH2COO-Cl

Azido-PEG1-CH2COO-Cl Chemical Structure

CAS No. : 79598-49-5

规格 是否有货
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生物活性

Azido-PEG1-CH2COO-Cl (compound 43a) is an alkyl/ether-based PROTAC linker. Azido-PEG1-CH2COO-Cl can be used in the synthesis of PROTAC BRD4 Degrader-1 (HY-133131)[1].

IC50 & Target[1]

Alkyl/ether

 

体外研究
(In Vitro)

PROTAC BRD4 Degrader-1 is an efficacious BRD4 degrader with an IC50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

163.56

Formula

C4H6ClN3O2
CAS 号

79598-49-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.Bioorg Med Chem. 2020 Jan 1;28(1):115228.

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