AMP-PCP

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

AMP-PCP 

AMP-PCP 是一种 ATP 类似物，可以以 Kd 值 为 3.8 μM 来结合到 Hsp90 的 N 末端结构域。AMP-PCP 结合有利于 Hsp90 活性同型二聚体的形成。

AMP-PCP

AMP-PCP Chemical Structure

CAS No. : 3469-78-1

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AMP-PCP 的其他形式现货产品:

AMP-PCP disodium

生物活性

AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90[1].

IC50 & Target[1]

HSP90

3.8 μM (Kd)

体外研究
(In Vitro)

AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

505.21

Formula

C11H18N5O12P3
CAS 号

3469-78-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542.

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