Lavoltidine(Synonyms: Loxtidine; AH-234844)

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Lavoltidine (Synonyms: Loxtidine; AH-234844)

Lavoltidine (Loxtidine) 是一种具有口服活性的，不可逆且高效的组胺 H2 受体拮抗剂。Lavoltidine 强烈抑制胃酸分泌，并诱发高胃泌素血症。

Lavoltidine(Synonyms: Loxtidine; AH-234844)

Lavoltidine Chemical Structure

CAS No. : 76956-02-0

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生物活性

Lavoltidine (Loxtidine) is an an orally active, irreversible and highly potent histamine H2-receptor antagonist. Lavoltidine strongly inhibits gastric acid secretion and also induces hypergastrinemia[1].

IC50 & Target

H2 Receptor

 

体内研究
(In Vivo)

Lavoltidine (Loxtidine; 0.5 g/L; orally (drinking water); changed weekly; for 3 months) shows partial suppression of both gastric acid secretion and progression to neoplasia. Lavoltidine inhibits gastric atrophy, hyperplasia, and dysplasia in H felis-infected INS-GAS mice[1].
Lavoltidine treatment for 6 months inhibits gastric tumors in H felis-infected INS-GAS mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male hypergastrinemic mice (INS-GAS mice) infected with Helicobacter felis[1]
Dosage: 0.5 g/L
Administration: Orally (drinking water); changed weekly; for 3 months
Result: Showed partial suppression of both gastric acid secretion and progression to neoplasia.

Clinical Trial

分子量

359.47

Formula

C19H29N5O2
CAS 号

76956-02-0
中文名称

拉伏替丁
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Takaishi S, et al. Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer.

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