Thalidomide-O-amido-PEG4-azide

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Thalidomide-O-amido-PEG4-azide 

Thalidomide-O-amido-PEG4-azide 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

Thalidomide-O-amido-PEG4-azide

Thalidomide-O-amido-PEG4-azide Chemical Structure

CAS No. : 2411681-89-3

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生物活性

Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

576.56

Formula

C25H32N6O10
CAS 号

2411681-89-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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