Mc-O-Si(di-iso)-Cl

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Mc-O-Si(di-iso)-Cl 

Mc-O-Si(di-iso)-Cl 是一种可降解 (cleavable) 的 ADC linker，可用于合成抗体偶联药物 (ADC)，例如 Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812)。

Mc-O-Si(di-iso)-Cl

Mc-O-Si(di-iso)-Cl Chemical Structure

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生物活性

Mc-O-Si(di-iso)-Cl is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812) )[1].

IC50 & Target[1]

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

331.91

Formula

C15H26ClNO3Si
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Finniss, M. C., et al. A versatile acid-labile linker for antibody–drug conjugates. Med. Chem. Commun., 2014, 5(9), 1355-1358.

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