N-Methylbenzamide

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N-Methylbenzamide 

N-Methylbenzamide 是一种有效的磷酸二酯酶 10A (PDE10A) 抑制剂。N-Methylbenzamide 具有抗癌活性。

N-Methylbenzamide

N-Methylbenzamide Chemical Structure

CAS No. : 613-93-4

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生物活性

N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor. N-Methylbenzamide has anti-cancer activity[1][2].

IC50 & Target[1]

PDE10A

 

体内研究
(In Vivo)

N-Methylbenzamide (compound 21; 100-800 mg/kg; ip; for 17 days) is active against tumor in donor female BDF mice (18-23 g)[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

135.16

Formula

C8H9NO
CAS 号

613-93-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kilburn JP, et al. N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors. Bioorg Med Chem. 2013 Oct 1;21(19):6053-62.

    [2]. Gate, E. N., et al. Structural studies on bioactive compounds. 4. A structure-antitumor activity study on analogs of N-methylformamide. Journal of Medicinal Chemistry, 1986, 29(6), 1046–1052.

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