m-PEG10-amine

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m-PEG10-amine 

m-PEG10-amine 是一种不可降解 (non-cleavable) 的含 10 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。m-PEG10-amine 还是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。

m-PEG10-amine

m-PEG10-amine Chemical Structure

CAS No. : 1383658-09-0

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生物活性

m-PEG10-amine is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

471.58

Formula

C21H45NO10
CAS 号

1383658-09-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jennifer Riggs-Sauthier, et al. Polymer-semaxanib moiety conjugates. US20140011855A1.

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