Propargyl-PEG4-Br

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Propargyl-PEG4-Br 

Propargyl-PEG4-Br 是一种 PROTAC 连接桥，属于 PEG 类。Propargyl-PEG4-Br 可用于合成一系列 PROTAC 分子。Propargyl-PEG4-Br 是一种不可降解 (non-cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。

Propargyl-PEG4-Br

Propargyl-PEG4-Br Chemical Structure

CAS No. : 1308299-09-3

规格 价格 是否有货 数量
100 mg ￥2000 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

Propargyl-PEG4-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Non-cleavable

 

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

295.17

Formula

C11H19BrO4
CAS 号

1308299-09-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Suzanne AKERS-RODRIGUEZ, et al. Compositions and methods for the treatment of bacterial infections. WO2019126353A2.

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