Azido-PEG5-alcohol

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Azido-PEG5-alcohol 

Azido-PEG5-alcohol 是一种不可降解 (non-cleavable) 的含 5 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。Azido-PEG5-alcohol 也是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。

Azido-PEG5-alcohol

Azido-PEG5-alcohol Chemical Structure

CAS No. : 86770-68-5

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生物活性

Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

IC50 & Target[1][2]

PEGs

 

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

263.29

Formula

C10H21N3O5
CAS 号

86770-68-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang FL, et al. Molecular-target-based anticancer photosensitizer: synthesis and in vitro photodynamic activity of erlotinib-zinc(II) phthalocyanine conjugates. ChemMedChem. 2015 Feb;10(2):312-20.

    [2]. Nan JI, et al. Mertk degraders and uses thereof. WO2020010210A1.

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