Azido-PEG5-CH2CO2H

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Azido-PEG5-CH2CO2H  纯度: 99.60%

Azido-PEG5-CH2CO2H 是一种可降解 (cleavable) 的含 5 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。Azido-PEG5-CH2CO2H 还是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。

Azido-PEG5-CH2CO2H

Azido-PEG5-CH2CO2H Chemical Structure

CAS No. : 217180-81-9

规格 价格 是否有货 数量
25 mg ￥900 In-stock
50 mg ￥1400 In-stock
100 mg ￥2200 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

Azido-PEG5-CH2CO2H is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-CH2CO2H is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

Cleavable

 

PEGs

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

321.33

Formula

C12H23N3O7
CAS 号

217180-81-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Yong Zu Kim, et al. Antibody-drug conjugates comprising branched linkers and methods related thereto. WO2017089895A1.

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