N-Boc-PEG7-alcohol

发表于由

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N-Boc-PEG7-alcohol 

N-Boc-PEG7-alcohol 是一种 PROTAC 连接桥，属于 PEG 类和 Alkyl/ether 类。N-Boc-PEG7-alcohol 可用于合成一系列 PROTAC 分子。N-Boc-PEG7-alcohol 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。

N-Boc-PEG7-alcohol

N-Boc-PEG7-alcohol Chemical Structure

CAS No. : 1292268-13-3

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生物活性

N-Boc-PEG7-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG7-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

425.51

Formula

C19H39NO9
CAS 号

1292268-13-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Julie Moreau, et al. Modular Synthesis of Bifunctional Linkers for Materials Science. European Journal of OrganicChemistry , 2011 ( 9 ) , 1641-1644.

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