N-Boc-N-bis(PEG4-OH)

发表于由

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N-Boc-N-bis(PEG4-OH) 

N-Boc-N-bis(PEG4-OH) 是一种 PROTAC 连接桥，属于 PEG 类。N-Boc-N-bis(PEG4-OH) 可用于合成一系列 PROTAC 分子。N-Boc-N-bis(PEG4-OH) 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。

N-Boc-N-bis(PEG4-OH)

N-Boc-N-bis(PEG4-OH) Chemical Structure

CAS No. : 2093154-01-7

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生物活性

N-Boc-N-bis(PEG4-OH) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-N-bis(PEG4-OH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

469.57

Formula

C21H43NO10
CAS 号

2093154-01-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Alain Wagner, et al. Intra-droplet surface engineering to capture a molecular target. WO2017174610A1.

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