Fmoc-NH-PEG8-CH2CH2COOH

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Fmoc-NH-PEG8-CH2CH2COOH 

Fmoc-NH-PEG8-CH2CH2COOH 是一种可降解的 ADC linker，用于抗体药物偶联物 (ADC) 合成。

Fmoc-NH-PEG8-CH2CH2COOH

Fmoc-NH-PEG8-CH2CH2COOH Chemical Structure

CAS No. : 756526-02-0

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生物活性

Fmoc-NH-PEG8-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Cleavable

 

PEGs

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

663.75

Formula

C34H49NO12
CAS 号

756526-02-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Fulcher JM, et al. Chemical synthesis of Shiga toxin subunit B using a next-generation traceless “helping hand” solubilizing tag. Org Biomol Chem. 2019 Dec 28;17(48):10237-10244.

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