m-PEG8-Amine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

m-PEG8-Amine 

m-PEG8-Amine 是一种可降解 (cleavable) 的 ADC linker，用于抗体偶联药物 (ADCs) 的合成。

m-PEG8-Amine

m-PEG8-Amine Chemical Structure

CAS No. : 869718-81-0

规格 价格 是否有货 数量
50 mg ￥500 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

生物活性

m-PEG8-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Cleavable

 

PEGs

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

383.48

Formula

C17H37NO8
CAS 号

869718-81-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Joshua D. Thoma, et al. Pyrrolobenzodiazepine antibody conjugates. WO2019126691A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务