m-PEG11-Amine

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m-PEG11-Amine 

m-PEG11-Amino 是一种可降解 (cleavable) 的 ADC linker，用于抗体偶联药物 (ADCs) 的合成。m-PEG11-Amine 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

m-PEG11-Amine

m-PEG11-Amine Chemical Structure

CAS No. : 854601-60-8

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生物活性

m-PEG11-Amino is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG11-Amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Cleavable

 

PEGs

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

515.64

Formula

C23H49NO11
CAS 号

854601-60-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Erwin R. Boghaert, et al. Anti-egfr antibody drug conjugates. WO2017214282A1.

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