Amino-PEG11-OH

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Amino-PEG11-OH 

Amino-PEG11-OH 是一种不可降解 (non-cleavable) 的 11 单元 PEG 类 ADC 连接物，用于抗体偶联药物 (ADC) 的合成。Amino-PEG11-OH 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

Amino-PEG11-OH

Amino-PEG11-OH Chemical Structure

CAS No. : 15332-94-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Amino-PEG11-OH is non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG11-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

Non-cleavable

 

PEGs

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

501.61

Formula

C22H47NO11
CAS 号

15332-94-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Synthesis of reduced sensitive azo connection unit and application of azo connection unit in DNA (deoxyribonucleic acid) sequencing. CN103539697A.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务