Amino-PEG10-OH

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Amino-PEG10-OH 

Amino-PEG10-OH 是一种不可降解 (non-cleavable) 的 10 单元 PEG-ADC 连接物，用于抗体偶联药物 (ADC) 的合成。Amino-PEG10-OH 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

Amino-PEG10-OH

Amino-PEG10-OH Chemical Structure

CAS No. : 129449-09-8

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生物活性

Amino-PEG10-OH is non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG10-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

Non-cleavable

 

PEGs

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

457.56

Formula

C20H43NO10
CAS 号

129449-09-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. James Bailey, et al. Non peptidic heterobivalent molecules for treating inflammatory diseases. WO2018134731A1.

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