4-Hydroxytolbutamide(Synonyms: Hydroxytolbutamide)

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4-Hydroxytolbutamide (Synonyms: Hydroxytolbutamide)

4-Hydroxytolbutamide (Hydroxytolbutamide) 是 Tolbutamide 的代谢产物。4-Hydroxytolbutamide 被在体内 CYP2C8 和 CYP2C9 代谢。Tolbutamide 是第一代钾通道阻滞剂，是一种磺酰脲类口服降糖药。

4-Hydroxytolbutamide(Synonyms: Hydroxytolbutamide)

4-Hydroxytolbutamide Chemical Structure

CAS No. : 5719-85-7

规格 价格 是否有货
5 mg ￥6200 询问价格 & 货期
10 mg ￥9800 询问价格 & 货期

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生物活性

4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].

IC50 & Target

Potassium channel
分子量

286.35

Formula

C12H18N2O4S
CAS 号

5719-85-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21(6):664-71.

    [2]. Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30(12):1311-9.

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