Mal-amido-(CH2COOH)2

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Mal-amido-(CH2COOH)2 

Mal-amido-(CH2COOH)2，化合物 7a，可用来合成亲水 ADC linker，是一种含马来酰亚胺乙基的中间体。

Mal-amido-(CH2COOH)2

Mal-amido-(CH2COOH)2 Chemical Structure

CAS No. : 207613-14-7

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生物活性

Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker[1].

IC50 & Target

Cleavable

 

体外研究
(In Vitro)

Mal-amido-(CH2COOH)2 is a intermediate for linker. Bivalent doxorubicin (DOX)-dipeptides (16a-c) are finally prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

ADC Linker

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

284.22

Formula

C11H12N2O7
CAS 号

207613-14-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Dubowchik GM, et al. Doxorubicin immunoconjugates containing bivalent, lysosomally-cleavable dipeptide linkages.Bioorg Med Chem Lett. 2002 Jun 3;12(11):1529-32.

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