(4R,5S)-Nutlin carboxylic acid(Synonyms: MDM2 ligand 2; E3 ligase Ligand 15)

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(4R,5S)-Nutlin carboxylic acid (Synonyms: MDM2 ligand 2; E3 ligase Ligand 15)

(4R,5S)-Nutlin carboxylic acid (MDM2 ligand 2) 是一种基于 Nutlin 3 的 MDM2 配体。(4R,5S)-Nutlin carboxylic acid 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子。

(4R,5S)-Nutlin carboxylic acid(Synonyms: MDM2 ligand 2; E3 ligase Ligand 15)

(4R,5S)-Nutlin carboxylic acid Chemical Structure

CAS No. : 2306390-08-7

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1 g 询价
2 g 询价

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生物活性

(4R,5S)-Nutlin carboxylic acid (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. (4R,5S)-Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTACs[1].

IC50 & Target

MDM2

 

分子量

639.53

Formula

C32H32Cl2N4O6
CAS 号

2306390-08-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.

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