Taccalonolide A(Synonyms: 根薯酮内酯A)

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Taccalonolide A (Synonyms: 根薯酮内酯A)

Taccalonolide A 是一种微管稳定剂，是从 Tacca chantrieri 中分离得到的类固醇，具有细胞毒性和抗疟活性。Taccalonolide A 能引起 G2-M 期滞留、Bcl-2 磷酸化，并引发细胞凋亡。Taccalonolide A 在体外对过表达 p 糖蛋白 (Pgp)、多药耐药蛋白 7 (MRP7) 的细胞系具有显著的抑制作用，抑制 SK-OV-3 细胞生长的 IC50 值为 622 nM。

Taccalonolide A(Synonyms: 根薯酮内酯A)

Taccalonolide A Chemical Structure

CAS No. : 108885-68-3

规格 价格 是否有货
5 mg ￥4030 询问价格 & 货期
10 mg ￥6860 询问价格 & 货期

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生物活性

Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities[1][2]. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis[1]. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells[3].

IC50 & Target

microtubule[1]
分子量

702.74

Formula

C36H46O14
CAS 号

108885-68-3
中文名称

根薯酮内酯A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tinley TL, et al. Taccalonolides E and A: Plant -derived steroids with microtubule-stabilizing activity. Cancer Res. 2003 Jun 15;63(12):3211-20.

    [2]. Risinger AL, et al. Taccalonolides: Novel microtubule stabilizers with clinical potential. Cancer Lett. 2010 May 1;291(1):14-9.

    [3]. Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68(21):8881-8.

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