Penitrem A(Synonyms: 青霉震颤素A)

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Penitrem A (Synonyms: 青霉震颤素A)

Penitrem A 是由青霉菌产生的吲哚二萜神经毒性生物碱，是一种选择性的 BK 通道拮抗剂，对多种恶性肿瘤具有抗增殖、抗侵袭作用。Penitrem A 能刺激脑皮质突触体增加内源性谷氨酸、GABA 和天门冬氨酸的自发释放，能诱发动物产生震颤综合征。

Penitrem A Chemical Structure

CAS No. : 12627-35-9

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生物活性	Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals^[1]^[2].
IC₅₀ & Target	BK channel^[1]
分子量	634.20
Formula	C₃₇H₄₄ClNO₆
CAS 号	12627-35-9
中文名称	青霉震颤素A
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Goda AA, et al. The Maxi-K (BK) Channel Antagonist Penitrem A as a Novel Breast Cancer-Targeted Therapeutic. Mar Drugs. 2018 May 11;16(5). [2]. Norris PJ, et al. Actions of tremorgenic fungal toxins on neurotransmitter release. J Neurochem. 1980 Jan;34(1):33-42.

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