Carbamazepine-d10(Synonyms: CBZ-d10; NSC 169864-d10)

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Carbamazepine-d10 (Synonyms: CBZ-d10; NSC 169864-d10)

Carbamazepine-D10 (CBZ-d10) 是 Carbamazepine 的氘代物。Carbamazepine (CBZ) 是压敏钠离子通道阻断剂，IC50 为 131 μM。

Carbamazepine-d10(Synonyms: CBZ-d10; NSC 169864-d10)

Carbamazepine-d10 Chemical Structure

CAS No. : 132183-78-9

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生物活性

Carbamazepine-D10 (CBZ-d10) is the deuterium labeled Carbamazepine. Carbamazepine (CBZ), a sodium channel blocker, is an anticonvulsant agent[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

246.33

Formula

C15H2D10N2O
CAS 号

132183-78-9
中文名称

卡马西平 D10
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22(3): p. 627-35.

    [3]. Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28(2): p. 143-53.

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