Fenofibrate-d6(Synonyms: 非诺贝特 d6)

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Fenofibrate-d6 (Synonyms: 非诺贝特 d6)

Fenofibrate-d6 是 Fenofibrate 的氘代物。Fenofibrate 是一种选择性的 PPARα 激动剂，EC50 为 30 μM。Fenofibrate 抑制细胞色素 P450 亚型, 对 CYP2C19，CYP2B6，CYP2C9，CYP2C8 和 CYP3A4 的 IC50 分别为 0.2，0.7，9.7，4.8 和 142.1 μM。

Fenofibrate-d6(Synonyms: 非诺贝特 d6)

Fenofibrate-d6 Chemical Structure

CAS No. : 1092484-56-4

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生物活性

Fenofibrate-d6 is the deuterium labeled Fenofibrate. Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

366.87

Formula

C20H15D6ClO4
CAS 号

1092484-56-4
中文名称

非诺贝特 d6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Schelleman H, et al. Pharmacoepidemiologic and in vitro evaluation of potential drug-drug interactions of sulfonylureas with fibrates and statins. Br J Clin Pharmacol. 2014 Sep;78(3):639-48.

    [3]. Gong Y, et al. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Sep 30. pii: S2352-3964(16)30448-0.

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