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Rosiglitazone-d3 (Synonyms: 罗格列酮 d3)
Rosiglitazone-d3 (BRL 49653-d3) 是 Rosiglitazone 的氘代物。Rosiglitazone (BRL 49653),是噻唑烷二酮类胰岛素增敏剂,也是选择性的,具有口服活性 PPARγ 激动剂,对 PPARγ1、PPARγ2 和 PPARγ 的 EC50 值分别为 30 nM、100 nM 和 60 nM。Rosiglitazone 与 PPARγ 结合,Kd 约为 40 nM。Rosiglitazone 也是 TRPC5 的激活剂 (EC50=∼30 μM) 和 TRPM3 的抑制剂。
Rosiglitazone-d3 Chemical Structure
CAS No. : 1132641-22-5
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生物活性 |
Rosiglitazone-d3 (BRL 49653-d3) is the deuterium labeled Rosiglitazone. Rosiglitazone (BRL 49653) is a selective, orally active PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively. Rosiglitazone binds to PPARγ with a Kd of approximately 40 nM. Rosiglitazone is also an activator of TRPC5 (EC50=~30 μM) and an inhibitor of TRPM3[1][2][3][4]. |
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体外研究 (In Vitro) |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
360.45 |
Formula |
C18H16D3N3O3S |
CAS 号 |
1132641-22-5 |
中文名称 |
罗格列酮 d3 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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