EGFR-IN-9 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

EGFR-IN-9

EGFR-IN-9 (化合物8) 是一种有效的 EGFR 激酶抑制剂，对于野生型 EGFR 激酶和双重突变型 EGFR 激酶 (L858R/T790M) 的 IC₅₀ 分别为 7 nM 和 28 nM。EGFR-IN-9 具有抗肿瘤活性。

EGFR-IN-9 Chemical Structure

CAS No. : 1226549-39-8

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性

EGFR-IN-9 (Compound 8) is a potent EGFR kinase inhibitor with IC₅₀s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). EGFR-IN-9 has antitumor activity^[1].

IC₅₀ & Target^[1]

EGFR (WT)

7 nM (IC₅₀)

EGFR^L858R/T790M

28 nM (IC₅₀)

体外研究
(In Vitro)

EGFR-IN-9 (Compound 8) shows antiproliferative activity in HCC827 lung cancer cell line with an IC₅₀ of 8 nM.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

476.53

Formula

C₂₉H₂₄N₄O₃

CAS 号

1226549-39-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Coumar MS, et al. Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor leadidentification. J Med Chem. 2010 Jul 8;53(13):4980-8.

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